In the most recent IUCN Red List assessment (2008), C. major was classified as Least Concern (LC). It is reported to occur in eight national parks (Andohahela, Andringitra, Mananara-Nord, Marojejy, Masoala, Midongy du Sud, Montagne d’Ambre, and Ranomafana), two strict nature reserves (Betampona and Tsaratanana), and three special reserves (Anjanaharibe-Sud, Mangerivola and Pic d’Ivohibe) (O’Connor et al., 1986; Nicoll and Langrand, 1989; Sterling and Rakotoaraison, 1998; Feistner and Schmid, 1999; Sterling and McFadden, 2000; Wright and Porter, 2004).
Based on the new Cheirogaleus taxonomy, the dwarf lemur species occurring in Zahamena National Park, Mantadia National Park, and the Analamazaotra Special Reserve at Andasibe (= Périnet), previously believed to be C. major, would now be C. crossleyi.
As of 2009, there were five individuals of this species in captivity, four in the Tsimbazaza Zoo in Antananarivo, Madagascar, and one in the Zürich Zoo, Switzerland (ISIS, 2009; I. J. Porton, pers. comm.).